Oncology Programs

LADR™ Technology Platform

Our innovative LADR™ (Linker Activated Drug Release) technology employs a broad portfolio of novel linker molecules that selectively bind to circulating albumin and have the ability to be linked to a wide variety of anti-cancer payloads. Our research efforts currently center on creating new molecules from the combination of ultra-high potency cytotoxic payloads with tunable linkers. The molecules that we are currently evaluating concentrate at the tumor site providing targeted delivery of the chemotherapeutic payloads.

View AACR 2018 Poster: Novel Maytansinoids (PDF)

View AACR 2018 Poster: LADR-9 and LADR-10 (maytansinoids) (PDF)

View AACR 2018 Poster: LADR-7 and LADR-8 (auristatins) (PDF)